Retinoids Progress in Research and Clinical Applications (Basic and Clinical Dermatology)

Description

This volume contains papers presented at the Conference on Retinoids: New Trends in Research and Clinical Applications held in 1991 in Palermo Italy describing the latest research findings on biochemistry nutrition molecular and cell biology and developmental biology as well as the pharmacology and the therapeutic use of vitamin A and its congeners.;Written by leading authorities in the field from the USA Europe and Japan Retinoids amongst other things: addresses retinol supported retinoic acid (RA) synthesis and catabolism; identifies synthetic ligands with a high selective affinity for RAR alpha beta and gamma nuclear receptors determining if they would show pharmacological properties similar to the natural parent substance all trans RA; considers the embryonic/foetal cellular retinoid binding proteins and evidence for their participation in normal and abnormal morphogenesis; discusses a novel arotinoid Ro 40 8757 that exhibited improved anti tumour efficacy and safety in pre clinical tests; and reports the audioradiographic distribution of retinol and RA in organs of pregnant hamsters and foetuses.

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